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Discovery and characterization of spike N-terminal domain-binding aptamers for rapid SARS-CoV-2 detection

Using in vitro liver models, we showed that these thiomethyl metabolites are directly linked to the elimination of the hepatotoxic NAPQI metabolites since S-CH 3 -APAP-S and SO-CH 3 -APAP-S are formed at high levels after exposure to NAQPI-derived metabolites (glutathione, cysteine, and mercapturate conjugates) in both primary human hepatocytes and HRG cells

However, only the loss of flagella ( fliC ) caused a major reduction in LCA-induced biofilm, with the other mutations causing either no change or only mild defects up to a ~25% reduction in crystal violet staining relative to the WT strain (Fig