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We propose that ROS stress is the initial step in LOsG-inducing prediabetes

We also assess enabling technologies such as spatial transcriptomics, proteomics, and patient-derived organoids, and discuss their translational relevance in stratifying metabolic vulnerabilities and informing individualized therapies

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By acting on separate but complementary receptor systems, this formulation provides a dual approach to studying endocrine signaling, pulsatile GH release, and metabolic regulation
