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The dosage ranges reported in this review are derived predominantly from observational evidence, including cross-sectional and questionnaire-based studies as well as retrospective self-reports from non-medical users, supplemented by case series describing adverse outcomes associated with supraphysiological androgen exposure

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Additionally, of note is that in one study on GERD, melatonin given at 3 mg daily over eight weeks showed similar improvement in symptoms as omeprazole [163]

This inconsistency is likely attributable to critical experimental variables such as species differences, dosage, exposure duration, and overall study design 73