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It is to note that both the cellular lipid hydroperoxides mediated by LOXs enzyme and autoxidized peroxyl radical-mediated LPO may contribute to initiate ferroptosis [38, 40]

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These medical disorders are probably caused by the extensive expression of angiotensin-converting enzyme 2 (ACE2) receptor (i.e., facilitator of SARS-CoV-2 entering cells) and many dysfunctional biological processes (such as chronic inflammation, endocrine disorders, immune disorders, tissue damage, tissue hypoxia, dysbacteriosis, coagulation and endothelial abnormalities, and neurological signal dysfunction) (Szabo et al., 2023

On the other hand, mTORC2 is linked to cell survival and actin organization (Takahara et al., 2020)

Despite the clear rationale for the use of antioxidants such as NAC as adjunct therapies in schizophrenia, clinical trials involving antioxidant administration to schizophrenic patients have led to equivocal results, with only a subset of trials finding statistically and clinically significant benefits [48,49,50]