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Cancer and drug-resistant tumors Resistance to commonly used alkylating agents or platinum chemotherapeutic drugs is often multifactorial, involving altered drug transport, biotransformation and enhanced detoxification capacity (Lu, 1999a)

Their meta-analysis pooled data from multiple clinical trials and used multivariable linear regression a statistical method that controls for confounding variables to extract the clearest possible signal from the noise

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This would mean comparing their impacts on SLE-specific immunological biomarkers such as autoantibodies titers, complement proteins (C3, C4), cytokines such as IL-6, IL-10, and TNF-, and T cell subsets (especially the Th17/Treg ratio), to assess efficacy and monitor disease progression, and clinical manifestations

doi: 10.1111/j.1749-6632.2002.tb02094.x