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Moreover, in a randomized, double-blind, placebo-controlled, phase 2 trial to validate the safety and efficacy of ebselen for the prevention of noise-induced hearing loss [84], 83 participants were allocated to receive 200, 400, or 600 mg ebselen or placebo before a calibrated sound challenge (4 h of pre-recorded music delivered by insert earphones)

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194, 195 Whether this constitutes an off-target mechanism of resistance or rather reflects the inhibition of caspase-9 by AKT1-transduced signals 196 (hence representing a post-target effect) remains to be clarified

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