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36 SchnaubeltD.QuevalG.DongY.Diaz-VivancosP.MakgopaM

Long-term levodopa treatment, while effective in alleviating motor symptoms, has been associated with increased oxidative stress and the generation of toxic metabolites, which can accelerate the loss of dopaminergic neurons

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It is worth noting that over 4 decades ago, GNMT expression was shown to be increased in ageing animals [142]

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