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After those 21 days, the pen must be discarded, even if it looks perfectly fine

Cuprizone-induced pathology mimics aspects of MS Histopathological analysis of post-mortem MS tissue revealed profound lesion heterogeneity both within and between MS patients [64,65,66]

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Without any clear rationale, the study outcome measures were purposefully modified midtrial to alter the findings in favour of their hypothesis (549, 550)
