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Because in M1 macrophages there is a reduced expression of the TCA cycle enzyme isocitrate dehydrogenase, citrate increases in mitochondria and is shuttled to the cytosol to be used for lipid synthesis (66)

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Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome

DOI: Published: Publisher Name: Springer, Cham Print ISBN: 978-3-319-69421-4 Online ISBN: 978-3-319-69422-1 eBook Packages: MedicineMedicine (R0)

however, in the case of vasculitis, it damages vascular endothelial cells [11]
