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Laboratory studies have examined how compounds such as 5-Amino-1MQ may influence energy utilization, adipose tissue signaling, and metabolic enzyme regulation

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A modified MISI computed on cubic splines of the measured data, resulting in improved identification of glucose peak and nadir, was compared with the original method yielding an increased correlation (=0.576) with the clamp measurement of peripheral insulin sensitivity as compared to the original method (=0.513)