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2 A fragment reproducing only a slice of that signaling may produce a real but modest lipolytic nudge enough to register as a statistically significant reduction in weight gain in a growing obese rodent, but too small to drive meaningful weight loss in a weight-stable human adult already dieting and exercising

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Briefly, adult zebrafish were anesthetized in 0.02% tricaine solution until gill movements slowed, decapitated, and eyes enucleated and placed vitreal side down on filter paper (0.45 m pore size

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