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Epigenetic and neurological effects and safety of high-dose nicotinamide in patients with Friedreich's ataxia: an exploratory, open-label, dose-escalation study

The MOR is associated with reward processing, while the D2R is linked to addiction

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Associations between BPV and neurological deficit (log-transformed NIHSS) at 24 hours and follow-up lesion volume (log-transformed FLV, ml) were assessed using linear regression adjusted for the number of measurements, age, sex, and baseline NIHSS

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