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doi: 10.1016/s1368-8375(99)00033-0

Pahl A, Lutz C, Hechler T

Toxic stress defines as the activation of the human bodys stress reaction system frequently and hardly reacting to long-term stressful stimuli or long-term activation of stress response to a stressful event with a failure of the human body

doi: 10.3109/09546631003801619 [DOI] [PubMed] [Google Scholar] 7.Handog EB, Datuin MS, Singzon IA

Due to the disabling symptoms which include cognitive and physical impairment worsened by exertion (1517), there is a significant economic burden created by ME/CFS (4) as many patients are unemployed and less than a fifth work full-time (11)