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PDX models have been successfully established from all major molecular MB subgroups and have demonstrated stability across multiple passages, although subclonal populations may undergo selection during serial transplantation

Neither is objectively "better" they serve different purposes with different delivery profiles

Anat Fecord Part A, Discov Mol, Cell, Evolut Biol 272(2):475483

Loading Protocols Some practitioners recommend a loading phase with higher initial doses followed by maintenance dosing