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Bertero A, Moretti A, Spicer LJ, Caloni F

Glutathione (GSH) plays an important role in antioxidant activities, redox (oxidation-reduction reaction)-regulated cell signaling, and immune responses (8)

The molecular mechanisms proposed to explain how ROS could specifically mediate brain damage are the following: (1) The lower levels of antioxidants can promote increased activity of lipoxygenase in CNS stimulating leukotriene production, thereby increasing the immunoinflammatory processes in the cerebral cortex

(1) Bio-safety Concerns

Following mitochondrial permeabilization, pro-apoptotic factors, including cytochrome c, are released into cytosol, leading to the formation of a caspase-activating complex (101,105)