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Taken together, these studies confirmed that live whole animal screens using C

Abbreviations LD: Lipid droplet CNS: Central nervous system TAG: Triacylglycerol DAG: Diacylglycerol CE: Cholesterol ester PC: Phosphatidylcholine PE: Phosphatidyl ethanolamine PI: Phosphatidyl inositol PS: Phosphatidylserine PA: Phosphatidic acid ER: Endoplasmic reticulum FIT2: Fat storage-inducing transmembrane protein 2 PLIN: Perilipin ATGL: Adipose triglyceride lipase ABCA: ATP-binding cassette transporter A Member ABCG1: ATP Binding Cassette Subfamily G Member 1 AD: Alzheimer's disease NLRP3: Nucleotide-binding oligomerization domain like receptor pyrin domain containing 3 OGD/R: Oxygenglucose deprivation/Reperfusion HSC70: Heat shock cognate protein MPTP: Methyl-4-phenyl-1,2,3,6-tetrahydropyridine HSL: Hormone-sensitive lipase FA: Fat acid ROS: Reactive oxygen species MDA: Malondialdehyde NF-B: Nuclear factor kappa-B FFAs: Free fat acids DGAT: Diacylglycerol O-Acyltransferase ACAT: Acyl-CoA cholesterol acyltransferase CGI-58: Comparative gene identification-58 Pnpla2: Patatin-like phospholipase domain containing 2 PPAR: Proliferator-activated receptor mTORC: Mammalian target of rapamycin complex FOXO: Forkhead box O PKA: Protein kinase A MGL: Monoglyceride lipase CMA: Chaperone-mediated autophagy LAMP2A: Lysosome-associated membrane protein 2A ATG: Autophagy related protein MAP1LC3/LC3: Microtubule-associated protein 1 light chain 3 LIR: LC3-interacting region GTPase: Guanosine triphosphatase PDM: Peridroplet mitochondria Sirt: Sirtuins AMPK: 5'-Prime-AMP-activated protein kinase PGC-1: Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha OxPhos: Oxidative phosphorylation NRF1/2: Nuclear respiratory factor-1/2 TFAM: Transcription factor A, mitochondrial HK: Hexokinase VDAC: Voltage-dependent anion channel OMM: Outer mitochondrial membrane OL: Oligodendrocytes FATP: Fatty acid transporters SLC: Solute carrier protein FABP: Fatty acid binding proteins LDAM: Lipid droplet-accumulating microglia Sig-1R: Sigma-1 receptor GalCer: Galactosyl ceramide LRP: Low density lipoprotein receptor-related protein TREM2: Triggering receptor expressed on myeloid cells 2 MCAO: Middle cerebral artery occlusion TGF-1: Transforming growth factor beta 1 TLR: Toll like receptor PUFAs: Polyunsaturated fatty acids GPCR: G protein-coupled receptor PGE2: Prostaglandin E2 IL-6: Interleukin 6 COX: Cyclooxygenase MCP-1: Monocyte chemoattractant protein-1 2-AR: Alpha-2-adrenergic receptors -AR: Beta-adrenergic receptor MCT: Monocarboxylic acid transporter HIF: Hypoxia-inducible factor I/R: Ischemia and reperfusion ApoE: Apolipoprotein E iPSCs: Induced pluripotent stem cells FAO: Fatty acid oxidation 25HC: 25-Hydroxycholesterol CH25H: Cholesterol 25-Hydroxylase SOAT1: Sterol O-acyltransferase 1 SREBP: Sterol regulatory element-binding protein SCAP: SREBP cleavage-activating protein Insig: Insulin-inducible gene protein TNF-: Tumor necrosis factor GSK-3: Glycogen synthase kinase 3 Nrf2: Nuclear factor erythroid 2-related factor 2 LPS: Lipopolysaccharide TAK1: TGF--activated kinase 1 MKKs: Mitogen-activated protein kinase kinases p38 MAPKs: Phosphorylated p38 mitogen-activated protein kinases AP-1: Activator protein-1 PI3K: Phosphatidylinositol 3-kinase AKT: Protein kinase B SFAs: Saturated fatty acids MUFAs: Monounsaturated fatty acids SPMs: Specialized pro-resolving mediators cPLA2: Calcium-dependent cytosolic phospholipase A2 alpha EPA: Icosapentaenoic acid DHA: Docosahexaenoic acid LOX: Lipoxygenases CYP: Cytochrome P450 GPCRs: G protein-coupled receptors STAT3: Signal transducer and activator of transcription 3 LAL: Lysosomal acid lipase qPCR: Quantitative polymerase chain reaction LPIN: Lipid phosphate phosphohydrolase LPL: Lipoprotein lipase GAMs: Glioma-associated microglia/macrophages EVs: Extracellular vesicles A: Amyloid peptides LDLR: Low-density lipoprotein receptor CYP46A1: Cholesterol 24S-hydroxylase 24-OHC: 24(S)-hydroxycholesterol LXR: Liver X receptor ABC: ATP-binding cassette References Tracey TJ, Steyn FJ, Wolvetang EJ, Ngo ST