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Loss of cytoplasmic bulk and reduction in size might be expected in situations of permanent loss of synaptic connections (e.g., trans-synaptic degeneration), as when central axons undergo Wallerian degeneration but fail to regenerate

SF supplementation also decreases oxidative stress caused by protein aggregation, a key factor in AD pathology

Interestingly, it is worth noticing that BBB as a carrier is extremely pivotal since glucose (also called fuel for the brain) transportation is vital for the appropriate functioning of the human brain and around 20% of the total body energy is used by the brain to work effectively [3, 6]