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Irritable Bowel Syndrome (IBS) and leaky Gut Syndrome Improvement of intestinal barrier function BPC 157 can up-regulate the expression of tight junction proteins (such as Occludin and ZO-1), enhance the integrity of the intestinal barrier, and reduce bacterial and toxin translocation

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Daily high doses of B12 may not likely cause harm in most people, but extremely high doses should possibly be avoided unless a healthcare professional prescribes it