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Description
Tirzepatide is FDA-approved for type 2 diabetes (as Mounjaro ) and weight loss (as Zepbound )

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Nadjsombati MS, McGinty JW, Lyons-Cohen MR et al (2018) Detection of succinate by intestinal tuft cells triggers a type 2 innate immune circuit
Surgical: Procedures like an abdominoplasty (tummy tuck), brachioplasty (arm lift), or lower body lift are the only proven ways to physically remove excess, hanging skin

Deficiency can develop gradually over years, as the liver stores significant amounts of B12typically enough to last 24 years
