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Yet another compound, Honokiol (HKL), has been shown to protect against doxorubicin-induced cardiotoxicity by activating SIRT3, which helps reduce ROS production, prevent mitochondrial fragmentation, and promote mitochondrial fusion 187

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Glutathione helps maintain cellular homeostasis by scavenging free radicals, regulating DNA synthesis and repair, protecting thiol groups in proteins, stabilizing cell membranes, and detoxifying xenobiotics