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Dysregulated cholesterol metabolism and fatty acid oxidation, mediated by key molecules such as TREM2 and ACAT1, lead to lipid droplet accumulation and pro-inflammatory activation in microglia (138,209)

[46] This dysfunctional state limits the tissue's ability to safely store lipids and decreases the baseline activity of critical metabolic regulators like AMPK

Ozempic (a GLP-1 receptor agonist) works by mimicking a hormone that increases insulin production and decreases sugar production in the liver

10.1007/s00232-001-0103-4 9