glutathione death Depletion and Stalwart Anticancer Activity of Metallotherapeutics Inducing Programmed Cell Death: Opening a New Window for Cancer Therapy Human cancer-associated fibroblasts enhance glutathione

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doi: 10.1016/j.celrep.2017.07.031 24 WangXEguchiAYangYChangLWanXShanJet al

The evidence is mechanistically consistent and promising, but has not reached the level required for FDA approval or clinical guideline inclusion

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Beyond defining a new regulatory axis, the work suggests that metabolic reprogramming may constitute an important layer intersecting SMC biology and aneurysm development