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[25] In addition to DNA methylation, other epigenetic mechanisms, such as histone modifications (chemical changes to the proteins that help package DNA) and non-coding RNAs (RNA molecules that regulate gene expression without encoding proteins), also influence ALDH2 regulation

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Shachar et al., 2004)

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Furthermore, IAP has no transmembrane domain owing to its GPI-anchored receptor 13 and cannot transduce cell signalling induced by IIAEK-IAP interactions