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LPS is considered a psychotic agent that can activate the neuroimmune response via toll-like receptors (TLRs) present in several neuronal cell types, including microglia, endothelial cells, and astrocytes, and generate free radicals, inflammatory cytokines, and other mediators to cause inflammation and oxidative stress [6]

Eur J Clin Pharmacol 1999

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Furthermore, during degeneration of H 2 O 2, change in the reduced (GSH) vs oxidised (GSSG) ratio triggers the initiation of several redox active signalling pathways in plants [7]
