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Clinical trial data with orforglipron have shown no signal for thyroid C-cell pathology or MTC
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Proteomics Reveals NNMT as a Master Metabolic Regulator of Cancer-Associated Fibroblasts
After one-third of the study participants have been enrolled and completed follow-up, the DSMBs will review the data and make recommendations concerning continuation, modification or termination of the study due to unexpectedly large beneficial effects or serious side effects and can suggest extension of the trial should the primary outcomes occur less often than anticipated
