glutathione peroxidase glutathione adduct of 4-hne Trapping 4-hydroxynonenal by efficiently prevents formation of DNA adducts in human cells Low Glutathione Level Favors Formation

Idarubicin in acute leukemia: results of studies at Memorial Sloan-Kettering Cancer Center

Simultaneously, CoQ10, an essential component of the mitochondrial electron transport chain, not only supports ATP synthesis but also modulates inflammation by inhibiting the release of pro-inflammatory cytokines and by down-regulating the NLRP3 inflammasome 53

After ferroptosis, excess intracellular free iron can enter the mitochondria, resulting in smaller myocardial mitochondria, increased mitochondrial membrane density, decreased mitochondrial respiration, and mitochondrial membrane potential depolarization (Sumneang et al., 2020), thus inducing CD and a series of Cardiac Diseases such as arrhythmia (Hu et al., 2021)

Fujiwara Y

& Geibl, F