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Methylglyoxal-mediated anxiolysis involves increased protein modification and elevated expression of glyoxalase 1 in the brain

Subsequently, the concentration of GSSG was measured colorimetrically, employing a method similar to that used for total glutathione determination, 36 and calculated using a calibration curve for GSSG solutions

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The production of uric acid can be decreased in the body (for example, by allopurinol, see below) or the excretion of uric acid can be increased (for example, by probenecid, see below)

Patients should be monitored for depression, suicidal thoughts or behavior, and any unusual changes in mood or behavior