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Astaxanthin reduces the expression of FN, ICAM-1, and TGF-1 induced by HG to reduce ECM deposition, and significantly promotes the nuclear translocation and transcriptional activity of Nrf2, and induction the expression of HO-1 [149, 150]

DISCUSSION The goal of this study was to develop an AngIV-derived molecule that retained the procognitive/antidementia activity of AngIV and Nle 1 -AngIV but possessed improved pharmacokinetic properties, thus allowing it to penetrate the BBB in sufficient quantities to reach therapeutic levels in the brain

doi: 10.1016/j.molp.2024.09.012 93 LiuT.LiY.DuanW.HuangF.HouX

GSTs are responsible for the first step in acrolein metabolization, consisting in its conjugation with GSH

10.3389/fnins.2020.00181 Front