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The primary theoretical safety concern is sustained activation of the HGF/c-Met proto-oncogenic pathway, which could theoretically promote tumor initiation or growth

Safety considerations may include: Blood sugar changes Water retention Injection site reactions Hormonal shifts Structured supervision reduces these risks

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It is suggested that this leads to an increase in the synthesis of cysteine and then the antioxidant glutathione, and thus represents a physiological feedback mechanism for limiting oxidative stress