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136 These findings suggest that Cu may contribute to the pathogenesis of HD by inhibiting key enzymes involved in lactate metabolism

Nrf2 and its downstream factor HO-1 exhibit both anti-ferroptotic and anti-inflammatory properties

These data suggest that plants and some microbial TyrA orthologs share an evolutionarily conserved substrate specificity mechanism, and that acquisition of the key active site acidic residue was crucial in evolution of arogenate-specific TyrA a enzymes in plants and closely-related microbes

Neither has been tested in humans, and both carry significant unknowns -- Dihexa with its retracted publication and oncological pathway concerns, PE-22-28 with its untested cognitive effects and potential seizure susceptibility