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Therapy with a GLP-1 RA or sodium-glucose cotransporter 2 inhibitor (SGLT2 inhibitor) that has proven CV benefit is recommended for initial therapy, with or without metformin based on glycemic needs, in patients with indicators of high-risk or established CV disease

Research published in peer-reviewed journals has explored B12-conjugated GLP-1 agonists specifically to test whether B12 attachment reduces central nervous system penetration while preserving peripheral metabolic effects

To treat them, you'll probably need shots of vitamin B12 at first, and then you may need to keep getting shots, or taking high doses of a supplement by mouth or nasally

Vitamin B12 is stored in the liver

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