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The signaling pathways include PI3K/Akt, Nrf2, and the mitochondrial regulators that contribute to such neuroprotective effects like enhanced performance of the brain, reduced cell death, and increased neuronal survival

This heavy metal enhances cAPX activity in pea at higher concentrations for longer periods of time, whereas it decreases and becomes constant beyond it (Panda and Matsumoto, 2010)

Microglial cells trigger neuroinflammation and neurodegeneration by producing pro-inflammatory cytokines [tumor necrosis factor- (TNF-), interleukin-6 (IL-6), IL-1] and reactive oxygen species (ROS) when they are persistently activated by abnormal stimuli, neurotoxic substances, infections, or injuries [11, 12]

doi: 10.3389/fnins.2018.00049 13

Other chemotherapy agents such us bortezomib or thalidomide produce a severe sensorimotor polyneuropathy with low amplitudes to all tested nerves
