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Despite numerous valid debates regarding the precise measurement of ROS production at the alternate site of the respiratory chain, there is a consensus on the controversy (Nair et al., 2018)

Diagnosis involves serum B12 measurement (levels below 148 pmol/L indicate deficiency

[DOI] [PubMed] [Google Scholar] 838.Mallozzi C, Di Stasi AM, Minetti M

B12 is essential for metabolic processes that convert food into energy