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Several factors, including cytokines, proteases, growth factors, gut microbiota, and dietary components are known to regulate intestinal TJs opening ( Intestinal epithelial cells and mononuclear phagocytes sense bacteria or their products mainly through pattern recognition receptors such as TLRs (166)

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It is reported that activation of ILC2s is partially dependent on TLR1, 2, 4, and 6 16,17

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