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In white adipose tissue, blocking NNMT elevated resting calorie burn, decreased adiposity, and improved insulin sensitivity in rodent models, independent of diet or activity changes (Kraus et al., Nature Medicine )

Nutrients 2021, 13, 2525

[DOI] [PubMed] [Google Scholar] 40.Nomme J, Antanasijevic A, Caffrey M, Van Itallie CM, Anderson JM, Fanning AS, Lavie A

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Circadian disruption is increasingly recognised as a key driver of: Accelerated aging Metabolic dysfunction Hormonal imbalance Cognitive decline Epitalon supports: Normalisation of sleepwake cycles Improved melatonin signalling Better alignment between central and peripheral clocks This explains why many individuals notice sleep improvement before other longevity effects