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Central to this crisis is the enzyme Dihydrolipoyl Succinyltransferase (DLST), the E2 core component of the 2-oxoglutarate dehydrogenase complex

There are five GRX subgroups that are classified according to their active site sequences, of which groups III and IV are specific to vascular plants

The protein that results from the use of the downstream UGA stop codon, due to readthrough translation, is identified as VDRAx

Wu H, Song W, Gao X, et al

Future studies are likely to explore additional combination therapies, particularly those involving drugs with distinct mechanisms of action, such as pairing iron chelators with antioxidants or mitochondrial protectants (64)