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Generally speaking, taking vitamin B12 is very safe, as any excess is excreted in the urine

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Wei et al., 2012) (Figure 5)

The enzyme was relatively stable over a pH range of 7.48.9, but it lost 93% of the original activity if the pH was raised to 9.8

However, in combination with zinc (critical for nervous, immune, and digestive system health) and vitamin C (a powerful anti-inflammatory and antioxidant agent), the master antioxidant effects of glutathione are multiplied
