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Conversely, some studies have shown that accumulated mutant p53 can interact with NRF2 to repress SLC7A11 expression, weakening GSH synthesis and rendering these cells more susceptible to oxidative damage (82)

As compared to control cells, the NADPH levels and the GSH/GSSG ratio were significantly decreased, whereas mitochondrial ROS and intracellular H 2 O 2 levels were increased in GDH1 knockdown cells [67]

Air-dried filters were placed in 5 ml of scintillation liquid (Ultima GoldTM, Perkin Elmer, United States), and the radioactivity incorporated was measured with a scintillation counter LS6500 (Beckman, United States)

Furthermore, mTORC1 also acts as a downstream effector of glutamine

Gedlicka C, Kornek GV, Schmid K, Scheithauer W
