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Similarly, a study that utilised the DOCA-salt model of hypertension observed increased plasma LPS and decreased colonic gene expression of occludin and ZO-1 [97]

Beyond adipose metabolism, 5-Amino-1MQ contributes to increased intracellular NAD+ availability , improving mitochondrial respiration and ATP synthesis

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Furthermore, this trend toward increased alpha diversity in the obese groups placed on an LD that had consequently experienced weight loss aligns with clinical observations, where low gene richness has been associated with increased adiposity, insulin resistance, and dyslipidemia 70 while increased gene richness has been observed following dietary intervention in obese and overweight individuals 71

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