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So to put it simple IGF is more effective at directly causing muscle growth and density increases

That is not a criticism

Pylvs, M., Puistola, U., Laatio, L., Kauppila, S

Main text Hallmarks of cancer metabolism Revisiting the Warburg effect: controversies and context The Warburg effect, characterized by the preference of cancer cells for aerobic glycolysis over oxidative phosphorylation, has long been a cornerstone of cancer metabolism research

Both proteins are essential regulators of the estrogen synthesis process and have a rate-limiting effect on the synthesis of steroid hormones, which may explain why GCs produce less estrogen