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This distinction suggests that pyroptosis may represent a more prioritized therapeutic target in the early or acute stages of disease, whereas ferroptosis inhibition strategies may hold unique value in the chronic phase or in patients with comorbid conditions such as iron overload or diabetes
While chronic exposure might partially normalize lipid oxidation via changes in gene expression and mitochondrial remodeling, the short-term effect is logically a decrease in exercise tolerance and potentially prolonged recovery
Steckel H, Eskandar F
Your body eats fat
