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This is especially common: In perimenopause With anovulatory cycles With chronic stress After exposure to environmental estrogens Estrogen Dominance in Men In men, estrogen levels can rise when: Testosterone declines (due to age, obesity, medications, or insulin resistance) Aromatase activity increases (converting testosterone into estrogen) Liver detoxification is impaired This leads to signs like gynecomastia (male breast tissue), belly fat, mood swings, and fatigue

Declaration of interests K.R., A.S., S.L

Neuron 12, 555570

Indeed, the addition of copper to disulfiram has been reported to enhance anti-tumor activity and reversing chemo-resistance in several drug-resistant cancer cells (98100)