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2018;9:e0232517

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Efficient methylation of catechol estrogens is, therefore, of foremost importance: during methylation, a methyl group is donated by S-adenosylmethionine (SAM) via COMT to ensure that catechol estrogens are converted to methoxyestrogens, thereby limiting the formation of genotoxic estrogen quinones 18
Excess iodine intake: sources, assessment, and effects on thyroid function

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