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Here, we performed in-depth metabolic profiling of CMV-specific CD8 + T cells in patients who are immunocompromised and show the development of metabolic dysregulation at the transcriptional, protein, and functional level of CMV-specific CD8 + T cells in KTRs with noncontrolled CMV infection

Its pathophysiology involves diverse mechanisms such as ectopic neuronal discharge, peripheral and central sensitization, dysregulation of ion channels, and disrupted balance between excitatory and inhibitory neurotransmission [43, 44]

Since the NF-B transcription factor family is implicated in a number of chronic disorders caused by inflammation, individuals with high NF-B levels may benefit from therapeutic targeting of NF-B