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Zhang YP, Eber A, Yuan Y, et al
Trials conducted between 2001 and 2007 demonstrated statistically significant reductions in body fat, although the larger Phase IIb OPTIONS trial did not replicate these findings at sufficient magnitude for regulatory approval, and formal development was discontinued in 2007
Novo Nordisk also released data from a sub-analysis of the phase 3 REDEFINE 1 trial, which investigated once-weekly cagrilintide 2.4 mg monotherapy in adults with obesity or overweight and a weight-related comorbidity, but without diabetes
When administered by a trained medical professional, B12 injections are extremely safe and well-tolerated
