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Interestingly, male adult rats exposed to THC during 10 days in adolescence display increased self-administration of synthetic cannabinoid agonist associated with decreased dopamine levels in the NAc, suggesting addiction-like behavior that occurs in parallel to increased anxiety-like behavior (Scherma et al., 2016)

This suggests that there might be different lipid metabolic pathways in the two subtypes of HF, and inhibiting myocardial energy deficiency, by restoring ATP-dependent LV relaxation and contraction, might cause beneficial effects in HFpEF [7]

10.1111/febs.13634 [DOI] [PubMed] [Google Scholar] Pignanelli M., Just C., Bogiatzi C., Dinculescu V., Gloor G

Journal of Cellular and Molecular Medicine, 15, 1703-1712

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