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It is thought that the first organ that becomes susceptible to autoimmune damage is the weakest link, where the person has a genetic predisposition or the organ has become damaged

It also increases the production of growth factors, such as vascular endothelial growth factor (VEGF), which improves blood flow to the injured area

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IGF-1 increased 1.5- to 3-fold for 9 to 11 days

If the damage goes on long enough, parietal cells can be lost entirely.[ref] Antibodies to parietal cells are found in 90% of patients with autoimmune gastritis