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While bioengineering approaches can enhance the successful engraftment of transplanted stem cells, EMFs can direct the cells migration and differentiation

In addition to the adverse effects of free radicals, excess oxygen levels have also been shown to alter cellular metabolism and activate several key signalling pathways that lead to hyperoxia-induced enzyme inhibition and cell death 61

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In turn, T cells produce inflammatory cytokines, such as IL-17 and IL-23, which exacerbate skin inflammation (206, 209)