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The SIRT1 expression is decreased in the high-fat diet (HFD)-induced DKD mice model and HG-treated SV40 MES13 cells, accompanied by the increased thioredoxin-interacting protein (Txnip) expression and nuclear translocation of XBP1s (a transcription factor that binds to Txnip promoters)
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It is important to note that weight loss in ALS patients is thought to occur independently of swallowing difficulties (dysphagia) and is not fully explained by denervationinduced muscle atrophy (Guillot et al
