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Exp Cell Res 307(2):292304 Ortega N, Werb Z (2002) New functional roles for non-collagenous domains of basement membrane collagens

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156,157 Recent successes with such strategies have resulted in high impact therapies including agents that block the p53-MDM protein interaction and the formation of antiapoptotic complexes by the Bcl2 protein with Navitoclax and Venetoclax

Adding more water simply means you will need to draw a larger volume of liquid to get the same milligram dose